Shifting my iterative alignment

I am working on a fixture with three tooling holes and stamped coordinates which are used for an iterative alignment to put the part in car space. It is very typical for the fixtures I work on to be done in this manner and I don't generally have any issues with just picking up using these tooling holes and moving on to measuring the part.

Now, my work has gotten a slew of new contracts and I am tasked with creating programs for a slew of new fixtures. with several of these fixtures I have found that after creating my iterative alignment using the tooling holes and stamped coordinates, the datum holes which locate the part on the fixture are not in the correct locations. So I understand from doing some reading that I should be able to use the datum hole deviations to shift my alignment.

Unfortunately I am mostly self taught with some help here and there from this forum or from my predecessor, and I have no experience doing something like this. I dont want to change my alignment to the datum holes of the part as that will move the part out of car space, so I guess I just need to tweak the theoretical location for the tooling holes? or can I just shift my alignment by the deviation found when measuring the tooling holes?

I appreciate any help!

im on 3.7 cad++